[5][6][7] The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1B.

This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation.

Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.

[8] Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome.

[13][14] TNFRSF1A has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.