However unlike the related TRIM24 and TRIM28 proteins, few transcription factors such as SMAD4 that interact with TRIM33 have been identified.

[8] This motif includes three zinc-binding domains: and a coiled-coil region.

[9] TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia.

[10] TRIM33 regulates also the TRIM28 receptor and promotes physiological aging of hematopoietic stem cells.

[12] This article incorporates text from the United States National Library of Medicine, which is in the public domain.