Tajikistan competed at the 2012 Summer Olympics in London, from 27 July to 12 August 2012.

A total of 16 athletes, 13 men and 3 women, competed in 7 sports.

Six of these athletes had competed in Beijing, including judoka Rasul Boqiev and freestyle wrestler Yusup Abdusalomov, who both won Tajikistan's first ever Olympic medals.

Tajikistan left London with only a single medal, following its successful Olympics in Beijing.

Boxer Mavzuna Chorieva, who won the bronze in women's lightweight division, set a historic Olympic record, as the nation's first female medalist in history, and first female flag bearer at the opening ceremony.