Talkalakh District (Arabic: منطقة تلكلخ, romanized: manṭiqat Talkalaḫ) is a district of the Homs Governorate in central Syria.

Administrative centre is the city of Talkalakh.

At the 2004 census, the district had a population of 129,429.

[1] The district of Talkalakh is divided into four sub-districts or nawāḥī (population as of 2004[1]):

This article about a location in Homs Governorate, Syria is a stub.