Witt is considered one of the most influential and famous Spanish speaking figures of Christian music.

[4] In 1994, Witt founded CanZion Institute, a school dedicated to the preparation of worship leaders and music ministers.

Twenty years later there are over 3,000 students attending the 28 campuses of the Institute in 10 different countries throughout the United States, Latin America, and Europe.

[8] Starting in 2002, for ten years he served as pastor of the Spanish Christian congregation at the megachurch Lakewood Church in Houston, Texas.

[5] As of 2023, Witt's music and outreach efforts have been credited as a factor behind the surging growth of Latino evangelicalism across the United States and Latin America.

[12] In September 2003, Witt received a Latin Grammy Award for Best Christian Album, for Sana Nuestra Tierra (Heal Our Land).

In November of that same year, he recorded Recordando Otra Vez (Remembering Once Again) at the LA Sports Arena.

This recording brought CanZion into the secular market because of its distribution agreement with Sony.In 2004, Marcos received his second Latin Grammy for Best Christian Album for Recordando Otra Vez.