[1][2] The organization has previously fielded teams in numerous other titles, including Call of Duty, Fortnite, Rainbow Six: Siege, PUBG, H1Z1, Clash Royale, Street Fighter, Formula 1, Hearthstone, Gears of War and Arena of Valor.

Team Vitality entered the professional League of Legends on 9 December 2015, after it acquired Gambit Gaming's spot in the 2016 EU LCS Spring Split.

Vitality then signed Kim "Mightybear" Min-soo, the former jungler of Newbee, and acquired bot laner Park "Police" Hyeong-gi from Apex Gaming.

[13] After winning a tiebreaker against FC Schalke 04, Vitality secured seventh place and avoided playing in the relegation series, although they also missed playoffs.

[18] Vitality instead ended up signing Lee "GBM" Chang-seok as a substitute mid laner,[19] as well as jungler Charly "Djoko" Guillard of the EU CS team Millenium.

[20] Top laner Adrien "Alderiate" Wils and support Baltat "AoD" Alin-Ciprian were also signed with the team as substitutes.

For the 2017 EU LCS Summer Split, Vitality signed support Oskar "Vander" Bogdan[22] and got picked into a nearly identical Group B with the recently promoted Mysterious Monkeys instead of Origen.

[23] The new roster surprised many with a 7–1 start to the spring regular season with their explosive playstyle; however, as other teams adapted to their strategies, Vitality began dropping games and finished fourth with a 10–8 record.

Vitality ended fourth in playoffs as well after defeating H2k 3–2 in the quarterfinals[24] and losing to Fnatic 1–3 in the semifinals and Splyce 2–3 in the third place decider match.

[25] Following a mediocre 5–5 first half of the 2018 EU LCS Summer Split, Vitality signed veteran jungler Mateusz "Kikis" Szkudlarek after week five, hoping that he could improve the roster with his experience.

[31][32] For the 2019 LEC Spring Split, Vitality acquired jungler Lee "Mowgli" Jae-ha from LCK team Afreeca Freecs.

[33] Vitality did not make any roster changes going into the 2019 LEC Summer Split and barely clenched a playoff spot after defeating SK Gaming in a sixth place tiebreaker match.

[36] Following this, the Xbox One Pro League shut down and Vitality picked up a PC roster which consisted of Bryan "Elemzje" Tebessi, Julian "Enemy" Blin, Dimitri "Panix" de Longeaux, Jean "RevaN" Prudenti, Valentin "Risze" Liradelfo, and Sami "Stooflex" Smail as coach.

In February 2018, Valentin "Voy" Cheron replaced Hansen, only weeks before the Six Invitational 2018, the Rainbow Six: Siege world championship, where they placed 13th–16th, the lowest possible placement in the tournament.

[38] This new roster performed better than the former, placing third in European Pro League Season 7, second in the Coupe de France 2018, and second at Dreamhack Valencia 2018, qualifying for the Six Major Paris 2018.

[39] While performing well at offline events, Vitality struggle online and placed seventh in European Pro League Season 8, and lost the relegation match to ENCE.

After being relegated to the Challenger League, Adrien "RaFaLe" Rutik and Florian "ZephiR" Perrot along with coach BiOs left to return to Supremacy.

[42] At Dreamhack Valencia 2019, Vitality defeated Korean team Cloud9 twice and lost to FaZe Clan in the group stage, and were eliminated in the quarterfinals by Chaos.

Additionally, Vitality defeated world champions G2 Esports 7–5 and lost only to Team Empire and Giants Gaming, who were placed first and second at the time respectively.

After season 10 of Pro League, Spark and Quaal were benched and replaced by two time world champion of Daniel "Goga" Mazorra Romero of G2 along with Lucas "Hungry" Reich of PENTA.

Team Vitality announced on 16 March 2021 that they were benching Fabian and Goga, two of the most decorated Rainbow Six players of all time, and the immediate release of Hungry.

[citation needed] Following the RLCS 2021–2022 Winter Major, Radosin from Williams Resolve was added to the starting roster and Fairy Peak!

[75] Similar to their entry into StarCraft II, this opportunity of recruitment may have been funded via the Saudi-operated Esports World Cup Club Support Program, of which Team Vitality is a member.

[73][74] On 28 May 2024, Team Vitality announced its return on the Street Fighter scene by welcoming two highly skilled player, the Canadian Sayff and the French Valentin "Valmaster" Petit.

Vitality also aims in the medium term to build an arena from 1500 to 2000 places inside the Stade de France to play its home matches.