It begins at Shady Valley and runs northward for about 11 miles (18 km) to the Tennessee–Virginia state border.

The highway heads north through farmland to pass through Crandull, where it begins to follow the former alignment of the Beaver Dam Railroad.

SR 133 then enters the mountains of the Cherokee National Forest, where it becomes curvy and narrow.

SR 133 then exits the mountains and the Cherokee National Forest to level and straighten out to pass through Sutherland before reaching its northern terminus at the state border with Virginia.

[1][2][self-published source][3] The entire route is in Johnson County.