State Route 161 (SR 161) is a north–south state highway located entirely in Robertson County in Middle Tennessee.

[1][2] SR 161 begins in Springfield at an intersection with US 431/SR 65 north of downtown in an industrial area.

The highway then leaves Springfield and continues northwest through farmland.

It passes through Barren Plains, where it has a Y-Intersection with SR 25.

SR 161 continues northwest to cross a bridge over the Red River before coming to the Kentucky state line, where SR 161 becomes Kentucky Route 102.