SR 220 begins at an intersection with US 70/SR 1/SR 104 (Broadway of America) in the community of Cedar Grove.

After a westward jog through Lavinia, it turns to the north-northeast, along the eastern edge of the Milan Army Ammunition Plant.

The highway then stairsteps its way to the northwest to the town of Atwood where the route meets its northern terminus, an intersection with US 70A/US 79 /SR 76/SR 77 (Main Street).

begins at an intersection with the SR 220 mainline (Church Street) in the southeastern part of Atwood.

At Norris Robinson Loop, the highway turns left and follows that road until they meet their northern terminus, an intersection with US 70A/SR 77 in the eastern part of town.