State Route 222 (SR 222) is a 12.9 miles (20.8 km) long north-south state highway in southern West Tennessee.

It connects the towns of Somerville and Stanton with Interstate 40 (I-40; Exit 42).

It heads northwest as a two-lane highway through farmland for several miles to an interchange with I-40 (Exit 42).

[2] The highway then crosses into Haywood County and temporarily widens to four-lane highway, bypassing the original two-lane alignment to the west, which is now known as Stanton Somerville Road.

SR 222 then narrows to two-lanes and enters Stanton as Lafayette Street, where it passes through some neighborhoods before coming to an end at an intersection with US 70/US 79/SR 1 just west of downtown.