SR 255 begins by heading east from Franklin Pike as Harding Place to cross I-65, US 31A/US 41A (Nolensville Pike/SR 11), and I-24.

After I-24, the route curves north as Donelson Pike to reach US 41/US 70S (Murfreesboro Pike/SR 1).

SR 255 provides access to Nashville International Airport.

It crosses I-40 and ends in Donelson at US 70 (Lebanon Pike/SR 24) in a commercial area.

[3] The entire route is in Davidson County.