It goes northwest to leave the Maryville city limits and pass through suburban areas to have a signalized intersection with Morganton Road.

The highway then passes by William Blount Highschool and several businesses before having a signalized intersection with Big Springs Road.

The highway then leaves the Maryville city limits for the last time and travels through a mix of farmland and suburbs before entering Alcoa at an intersection with Middlesettlements Road.

The highway passes through neighborhoods before following along the southern edge of McGhee Tyson Airport to have an interchange with US 129 (Alcoa Highway/SR 115).

SR 335 goes east as E Hunt Road through a mix of farmland and suburbs before crossing the Little River and entering Eagleton Village.