It connects US 11E in Russellville to US 11W west of Rogersville, Tennessee via SR 113.

[2] SR 344 begins in Hamblen County in Russellville at a Y-Intersection with US 11E/SR 34/SR 66.

The highway goes east along the original US 11E alignment through downtown (Old Russellville Pike) before leaving Russellville and turning northeastward through farmland before having an intersection and becoming concurrent with SR 113, where it crosses into Hawkins County.

It then passes through a couple of ridges before making a sharp right and crossing a bridge over Cherokee Lake/Holston River a short distance later.

SR 344 then comes to an end at an intersection with US 11W/SR 1 just west of Rogersville.