SR 113 begins as a 2-lane highway in Jefferson County east of Dandridge at an intersection with US 25W/US 70/SR 9.

The highway then continues north through farmland to White Pine, where it has an intersection with SR 341.

SR 113 then continues through the center of town to intersect and become concurrent with US 25E/SR 32, shortly before they cross into Hamblen County.

US 25E/SR 32/SR 113 continue north to leave White Pine and go through farmland to come to an interchange with I-81 (Exit 8), where it widens to a 4-lane divided highway and enters Morristown.

The numbering change was requested by area residents due to confusion with SR 66.