It serves the town of Mosheim and the communities of Midway, McDonald, Mohawk and Warrensburg.

SR 348 begins at an intersection with SR 340 (Fish Hatchery Road) in extreme western Greene County.

Before the route reaches Midway it passes through a small community called McDonald, it has only a volunteer fire department and an elementary School and of course some houses.

In Midway SR 348 comes to an intersection with Midway Railroad Street which goes east and SR 348 turns south for a very short time and comes to a three-way intersection at which McDonald Road ends, Little Chuckey Road goes south and SR 348 turns east onto Midway Road.

SR 348 passes over a railroad line and enters Mosheim city limits and passes West Greene High School and comes to an end at an intersection with US 11E/SR 34.