[5] Yangco established a shipping company, organized a bus company called TRY TRAN, set up a shipyard, and founded a big department store named Bazar Siglo XX and a huge dry-goods market in Divisoria called Yangco Market.

[7] He followed his father's practice of investing his surplus earnings in properties suitable for commercial purposes.

In 1923, he represented it in the first Pan Pacific Commercial Conference in Honolulu, Hawaii where he eloquently defended the cause for Philippine independence.

Yangco donated large sums of money to various charitable, religious and civic organizations.

[13] One of the biggest properties he donated was the 31,031 square meter lot in a commercial area in Manila that became the site of YMCA of the Philippines.