Termination signal

Termination signals bring a stop to transcription, ensuring that only gene-encoding parts of the chromosome are transcribed.

[1] In the context of translation, a termination signal is the stop codon on the mRNA that elicits the release of the growing peptide from the ribosome.

[4] These antitermination mechanisms are crucial when the cell is under stress, allowing for increased expression of downstream genes that are needed under dire circumstances.

[3] Due to termination inefficiency, read-through can result in increased regulation of downstream genes that may be crucial to host cell function.

[2] Traditionally, the termination signal for translation is a 3 nucleobase sequence called a stop codon.

[2] Specifically, the 4th base (nucleobase directly following the stop codon) has a significant impact on the termination efficiency.

[2] It has been found that highly expressed genes have higher termination efficiency due to the presence of a purine in the 4th position.

Overview of transcription process. Termination of transcription occurs due to termination signal.
Intrinsic terminator containing an RNA hairpin rich in guanine and cytosine as well as a region high in uracil