Tetrahydroquinoline is an organic compound that is the semi-hydrogenated derivative of quinoline.

Substituted derivatives of tetrahydroquinoline are common in medicinal chemistry.

[1] Oxamniquine, dynemycin, viratmycin, and nicainoprol are bioactive tetrahydroquinolines.

[2] Typically tetrahydroquinoline derivatives are prepared by hydrogenation of the corresponding quinoline using heterogeneous catalysts.

Because the hydrogenation is reversible, tetrahydroquinoline has been often examined as a hydrogen-donor solvent in coal liquifaction.