[3] The first member of this genus was identified in 2001 in pig serum and designated Porcine parvovirus 2.

They were isolated from a group of patients who had engaged in high risk behavior.

[11] Tetraparvoviruses are small, non enveloped animal viruses with a single-stranded DNA genome between 4 and 6 kb in length.

The third ORF encodes a small protein with a single transmembrane helix spanning 20 amino acid residues in the centre.

These viruses have been isolated from blood, liver, spleen, lymph node and bone marrow.