[2] The route proceeds to the northeast almost immediately intersecting from the south FM 769 which runs closely parallel to the state line on the Texas side.

SH 125 continues to the northeast to Bledsoe where the route intersects FM 2182[3] before turning east along Third Street.

[3] In Lehman, the route joins SH 214 to the south for a short distance before turning east again.

[5] SH 125 passes through mostly agricultural lands and oil and gas fields across the largely flat and featureless terrain of the Llano Estacado.

[6][7] SH 125 was previously designated on September 7, 1927[8][9][10] on a route from Anahuac to Beaumont in Chambers and Jefferson counties.

[21] FM 769 was extended 8.5 miles (13.7 km) farther south along the state line to US 83 west of Denver City on January 26, 1969.