[2] The route was originally designated on January 18, 1935,[3] from Muleshoe to the Bailey County line.

[9] On March 27, 1940, The section from Friona south to Muleshoe was removed.

On August 27, 1940, the section of SH 214 through Yoakum County was cancelled, creating a gap.

On December 19, 1940, the section from Plains south to the Yoakum–Gaines county line was added back.

On June 10, 1966, the extension to Friona was officially designated, replacing FM 299.