SH 110 begins at an intersection with US 84 and Loop 62 in downtown Rusk and leaves the courthouse square north with US 84, crossing US 69 on its way to a split on the northeast side of Rusk where US 84 goes off east and SH 110 turns north, out of town.

Just after Garden Valley, the road multiplexes with FM 16 and goes west into Van Zandt County.

SH 110 splits with FM 16 in Van and turns back north.

[4] The branch to Rusk was not added to the state highway log until November 30, 1932.

On May 15, 1934, the original portion had been renumbered as SH 204, leaving the routing from Rusk to Tyler.