The route will run from I-69C/US 281 in Edinburg, intersecting I-2/US 83 in Donna, to the future SH 365 toll road in San Juan.

The route was originally designated on August 21, 1923 to replace SH 10A between Stephenville and Dallas.

On March 26, 1942, the remaining route was deleted in favor of the newly formed Farm to Market Road system, with part being redesignated FM 8.

The current SH 68 designation was assigned on February 28, 2013, consisting of the segment from I-69C/US 281 Edinburg to I-2/US 83 in Donna.

[5] On August 16, 2023, TxDOT approved a southern extension of SH 68, to run southward from I-2/US 83 in Donna and then westward, partly concurrent with FM 3072, to the proposed SH 365 toll road.