SH 349 (Big Spring Street), the southern frontage road serves as the northern boundary for Midland Airpark.

Just east of Fairgrounds Road, freeway status ends and Loop 250 continues as a divided highway.

The highway leaves the city limits of Midland just east of County Road 1160.

Loop 250 was originally designated on March 31, 1952 and ran from US 183 near the Montopolis Bridge to US 81 in north Austin.

Media related to Texas State Highway Loop 250 at Wikimedia Commons