[1] Spur 422 begins at an intersection with Loop 410 and SH 16, near Palo Alto College.

Northbound SH 16 follows westbound Loop 410, while northbound Spur 422 continues north along the Poteet-Jourdanton Freeway.

[1][2] Spur 422 is a former route of SH 16, and was designated (along with Spur 421[3]) on November 16, 1965, after SH 16 was rerouted around the west side of San Antonio along the Loop 410 freeway.

[1] Originally, the highway had a direct interchange with I-35 at its northern end.

The entire route is in San Antonio, Bexar County.