I-410 circumnavigates the city of San Antonio, officially beginning and ending at the junction with I-35 on the southwest side of the loop.

The northern arc serves the heavily urbanized portions of San Antonio and is currently being widened to as many as five lanes in each direction.

I-410 serves San Antonio International Airport, Lackland Air Force Base, Fort Sam Houston, the South Texas Medical Center, Southwest Research Institute, and Toyota Motor Manufacturing Texas.

By 1967, the eastern arc had been completed to Interstate Highway standards, and the remaining portion from US 281 to I-35 on the city's north side had been completely built to Interstate Highway standards but still carried the Loop 410 designation until July 31, 1969, when it officially became I-410.

I-410 was widened from the late 1990s through early 2010s along its entire northern arc from Culebra Road to Austin Highway, with five lanes each way and interchange reconstructions at I-10 and San Pedro Avenue, and an entire new interchange at US 281,[5][6] officially called the "San Antonio Web".