He studied drawing at the Athens School of Fine Arts (Σχολή Καλών Τεχνών, Scholi Kalon Technon), at the workshop class of the professor Yiannis Moralis.

He played in many roles of the classical repertoire with other actors, including Katina Paxinou, Alexis Minotis, Cybele, Christoforos Nezer, Stelios Vokovits, Thanos Kotsopoulos, and Dimitris Horn.

Thanos Leivaditis also participated in international film festivals at Théâtre des Nations (Paris) in 1962 and at the World Theatre Season (London) in 1966.

The next phase of his career involved television, beginning in 1974 when he starred in Oi Dikaoi (which lasted three seasons).

He was a screenwriter and a playwright for his roles as the judge Angelos Karnezis and the journalist Aris Martelis.