[15] Helen Mirren reprised her role of Queen Elizabeth II in this production,[16] alongside fellow original cast members Geoffrey Beevers, Michael Elwyn, Richard McCabe and Rufus Wright.

Other current events references made during the audience scene between the Queen and Cameron included the corruption scandal at FIFA and the Greek bailout debate known as "Grexit".

During the last week of the run, a reference was made to newspaper articles displaying the Queen apparently making a Nazi salute in her youth and to the birthday of Prince George.

In May 2017, the play received its Russian premiere in Moscow and starred Inna Churikova as the Queen, along with Mikhail Gorevoy as Winston Churchill and Galina Tunina as Margaret Thatcher.

[24] The Toronto cast included Paul Essiembre as Eden, Kate Hennig as Thatcher, Benedict Campbell as Brown, Kevin Klassen as Blair and Ben Carlson as Cameron.

[24] The 'Traviata' model handbag by British designer Launer London received a surge in popularity and was subsequently re-issued by the brand following the use of one as a prop in The Audience both in the West End and on Broadway.

[25][26] Specific episodes of the Netflix series The Crown, created by Peter Morgan, acknowledge inspiration from The Audience, produced by Playful productions LLP, Robert Fox LTD and Andy Harries.