TCAG also operates as a Science and Technology Innovation Centre of Genome Canada,[1] with an emphasis on next-generation sequencing (NGS) and bioinformatics support.

A genome-wide microsatellite genotyping laboratory at the Ottawa Health Research Institute, led by Dennis Bulman, was added.

This provided operational support, enhancing existing facilities and adding a mouse genotyping core at the University of Toronto led by Lucy Osborne.

[2] In 2004, TCAG entered a second phase of development driven by a $12 million CFI/Ontario Innovation Trust funded project entitled "Integrative Genomics for Health Research",[3] allowing for consolidation of the mouse genotyping core with the SickKids facilities.

This award also supported the establishment of an "Ontario Population Genomics Repository" (OPGP) to be used as controls in studies of common diseases.

To efficiently complete this project, TCAG partnered with John McLaughlin's group at Mount Sinai Hospital (Toronto).

Further enhancements to the TCAG infrastructure were supported by a $10.7 million renewal grant from CFI's Leading Edge Fund competition, entitled "Integrative Genomics for Health Research – Phase II", awarded in June 2009.

Service work is also performed for over 600 other academic, private sector and government labs each year, drawn from 30 different countries and spanning a wide variety of research disciplines.

In 2008, TCAG Scientific Directors, Associate Scientists and staff co-authored 58 peer-reviewed manuscripts dependent in some way (either entirely, or in part) on the platform infrastructure, as documented in PubMed.

The facility uses conventional capillary Sanger sequencing on Applied Biosystems 3730xl instruments, governed by a Laboratory Information Management System (LIMS).

The Microarray and Gene Expression Core Facility has a dedicated manager, and operates technologies from Affymetrix, Agilent and Illumina.

The Genome Resources components includes a clone repository (Mammalian Gene Collection (MGC) cDNA (mouse and human), genomic clones including human bacterial artificial chromosomes (BACs)) and provides project consultation and design assistance (annotation, database queries, probe selection).

The scientific management committee consists of: Bader and Brudno are located at the University of Toronto, and the others at The Hospital for Sick Children.