[2][3] During 1875, an eleven-room house was rented for CA$320 (equivalent to $9,327 in 2023) a year by a Toronto women's bible study group, led by Elizabeth McMaster.

The building, known as the Victoria Hospital for Sick Children, is now the Toronto area headquarters of Canadian Blood Services.

The research that led to the discovery of insulin took place at the nearby University of Toronto and was soon applied in the hospital by Gladys Boyd.

[17] A second proposal was titled “Stop COVID in Kids - School based vaccine education outreach to build trust and empower families”, which received additional funding in the form of a $440,000 grant from the Public Health Agency of Canada's Immunization Partnership Fund.

[14][18] In 1980-81, up to 29 baby deaths at SickKids were suspected to have been deliberate murders by a nurse using the heart medication digoxin.

However, after years of inquiry it remains unclear if any murders actually took place or if toxicological tests were misinterpreted.

In 2024, retired SickKids paediatric intensive care specialist Dr. Desmond Bohn, who took the latter position, pointed to similarities in the British Lucy Letby case.

Lang also stated, "That SickKids failed to exercise meaningful oversight over MDTL's work must be considered in the context of the hospital's experience with Dr. Charles Smith.

In 2017, it established the "SickKids VS Limits" fundraising campaign, which continued until 2022 to raise $1.5 billion for the expansion project.