[1] The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21[2][3][4] throughout the region.

The hospital has a rooftop helipad and is an ACS verified level 1 pediatric trauma center, the only one in Oklahoma.

[13] In 2022, after Republicans in the Oklahoma Legislature introduced legislation to block $39.4 million dollars in federal funding granted to the hospital under the American Rescue Plan Act unless it ceased providing gender affirming healthcare to trans youth, the hospital announced it would cease providing gender affirming healthcare to trans youth.

[14][15][16] Oklahoma Children's Hospital has the only American Academy of Pediatrics verified level IV neonatal intensive care unit (NICU) in the state and the greater region of the midwest.

Critically ill newborns from all over the region are transported to the NICU from smaller hospitals that are not equipped to treat these patients.

[19] In 2012, the Mother & Baby Center at Oklahoma Children's Hospital received an "Excellence in Patient Care" award from the healthcare firm Studer Group.