It is the oldest hospital in the state[1] and one of 19 operated by SSM Health, a not-for-profit Roman Catholic care provider.

When they arrived in Oklahoma City they approached the pastor of St. Joseph's Catholic Church to petition the congregation.

The Sisters were approved to raise funds with the condition that any money raised would go towards opening a hospital in Oklahoma City since the newly established and rapidly growing Oklahoma Territory did not have a hospital and its citizens were dying from lack of care.

The Sisters agreed, and on August 1, 1898, they opened St. Anthony Hospital in a small house that had twelve beds.

The Saints Pavilion, which represents one of the pivotal milestones of the renewed campus and commitment to Midtown, was completed in 2003.