On the Easter Sunday of 1959 this proposition came to fruition when Baptist Memorial Hospital opened its 200-bed facility in Oklahoma City.

Later in 1965, South Community Hospital was opened after hosting a fund drive to raise the money necessary the construction of the facility .

[10] Later in 2013, Integris became a preferred clinical affiliate of Access Medical Centers, offering patients an urgent care alternative to the emergency room.

[11] In 2014, Integris launched an online video platform, integrishealth.tv to provide a place for patients and family members to learn about their services and educate the community about health issues.

[20] ICIO serves more than 3.6 million people in the Southwest area, mainly Oklahoma,[21][22] and residents from North Texas, Kansas, and Arkansas.

[26] In 1995 Integris also created the Basic Education Empowerment Program (BEEP) to help at-risk youths turn their lives around.