As in the television series, the film depicts the adventures of cousins Bo, Luke, and Daisy, and their Uncle Jesse, as they outfox crooked Hazzard County Commissioner Boss Hogg and Sheriff Rosco P. Coltrane.

Cousins Bo, Luke, and Daisy Duke run a moonshine business for their Uncle Jesse in Hazzard County, Georgia.

The cousins' primary mode of transportation is an orange 1969 Dodge Charger that the boys affectionately refer to as the "General Lee".

After Rosco has the General Lee vandalized after Bo and Luke's attempt to run away from a daughter of one of their many moonshine customers, Billy Prickett, a famous stock-car driver, enters Hazzard to participate in the rally.

Meanwhile, Rosco plants a fake moonshine still in Uncle Jesse's barn and seizes the Duke property in the interest of eminent domain for Boss Hogg, forcing the family to temporarily reside with neighbor Pauline.

Meanwhile, Cooter Davenport turns the General Lee into a hot rod in hopes of finally receiving payment for all the work he has done for the boys in the past if they win the race.

The Dukes go to Atlanta to visit a local university geology lab, meeting with Katie-Lynn Johnson, a Hazzard county girl.

The two race to the farmhouse to cause a distraction to the waiting Hazzard County Sheriff's deputies and Georgia State Troopers, while Daisy and Cooter rescue Jesse and Pauline.

Upon crossing the finish line first before Billy, the two then continue racing across town, leading the townsfolk to the courthouse, where the proposal is rejected.

Boss Hogg attempt's to have the boys locked up but Daisy takes advantage of the governor of Georgia's presence and TV cameras to convince him to pardoning them.

Knoxville said he was initially reluctant to take on the role, but was persuaded by script changes and the presence of Dan Bradley as stunt coordinator and second unit for the car chase scenes.

The website's consensus called the film "A dumb, goofy, and vacuous adaptation of a TV show where plot is simply an excuse to string together the car chases.

Before the release of this film, Warner Bros. reportedly paid $17.5 million to the producer of Moonrunners, the movie that inspired the television series.

Performed from the point of view of her character in the movie, Simpson's cover was co-produced by Jimmy Jam and Terry Lewis, and was released as the soundtrack's first single in 2005.