The Environmental Determinants of Diabetes in the Young

An increasing body of evidence, including rising rates of T1D diagnosis and incomplete penetrance of the disease in genetically predisposed individuals, suggests that environment may play an equally important role.

Study participants also provide a range of samples designed to give a comprehensive view of their exposure to environmental factors which could possibly trigger or protect against the development of autoimmunity and T1D.

Samples collected for analysis include blood, nasal swabs, saliva, urine, stool, toenails, and drinking water.

[6] Potential TEDDY subjects were identified at birth by genetic screening of the HLA-DR/DQ loci, which are considered to be highly important in determining whether an individual will develop Type 1 Diabetes.

[8] DKA is a serious complication which is particularly common in children under five years of age and can lead to cerebral edema, coma, and death.