[2] Both Davis and producer Mark Evanier, who previously wrote episodes for the 1988 original cartoon animated series Garfield and Friends, co-wrote stories for the program, with the cast including Frank Welker, Wally Wingert, Julie Payne, Jason Marsden and Gregg Berger.

The animated series premiered on 22 December 2008 in France as Garfield & Cie, in early 2009 in Japan as Gāfīrudo to shī, and on 2 November 2009 in the United States.

Liz is now considered a main character and has an official relationship with Jon to reflect their current status in the comic strip.

Squeak, Garfield's mouse friend that lives in Jon's house, also appears, having previously in the comic strip.

[9] Common Sense Media gave the show 3 stars out of 5, saying "Infamous cat's antics are fun, if not exactly message laden.

He concluded his review stating he preferred "old-school cell animation as the week-to-week series CGI looks too much like cheap video game emulations, but I’m not the target market of these things".

The animation is a tad rudimentary and clunky at times, but it's good enough to pass muster for cartoon fare of this type.