[9][10] Walt Disney Records released a series soundtrack album digitally and on streaming on May 10, 2023.

[11] The soundtrack reached number 1 on the Billboard Kid Albums chart—the first time the Muppets have ever topped a Billboard chart—and peaked at number 10 on the Soundtracks chart, earning 5,000 album-equivalent units in its first week.

[12] The Muppets Mayhem soundtrack received a positive review from Daps Magic who commented that "The soundtrack for The Muppets Mayhem is a wonderful release that is a lot of fun to listen to and is really well done.

It was released by Walt Disney Records as a vinyl LP on May 12, 2023, two days after the series' premiere.

The packaging of the album consisted of a cover art by Matt Taylor and layout by Sean Tejaratchi, and two colored 180-gram vinyl LPs: translucent blue/purple swirl and psychedelic green.