[1][2] Each episode of the season covers one hour of a single 15-hour emergency department shift at the fictional Pittsburgh Trauma Medical Hospital.

The series is created and showrun by R. Scott Gemmill who is also an executive producer alongside Noah Wyle, John Wells, Erin Jontow, Simran Baidwan, and Michael Hissrich.

[1] On July 12, 2024, Tracy Ifeachor, Patrick Ball, Supriya Ganesh, Fiona Dourif, Taylor Dearden, Isa Briones, Gerran Howell, Shabana Azeez, and Katherine LaNasa joined the cast as series regulars.

[12] On August 14, 2024, Shawn Hatosy, Michael Hyatt, Jalen Thomas Brooks, Brandon Mendez Homer, Kristin Villanueva, Amielynn Abellera, Alexandra Metz, Krystel V. McNeil, and Deepti Gupta were cast in recurring capacities.

The website's critics consensus reads, "Setting the trials and tribulations of hospital life on a timer, The Pitt combines multiple tried-and-true formulas to create a bracingly fresh medical drama.