The main star of the book is Jessica Jones, a former superhero and private investigator, previously seen in the Alias series.

Jones works as a specialist consultant for "The Pulse" with journalists Ben Urich and Kat Farrell.

Other cast members include Luke Cage, superhero and boyfriend to Jessica, the Bugle's publisher, J. Jonah Jameson, and senior editor Joseph "Robbie" Robertson.

After an extended battle with Spider-Man and Luke Cage, the Goblin is arrested and sent to prison for the first time in the character's 40-year history.

In a House of M tie-in, Kat Farrell meets Hawkeye, who is alive in this reality and despondent over recovering the memory of his life in the regular 616 universe (most specifically his death at the hands of the Scarlet Witch).