The series follows the exploits of Keima Katsuragi, an intelligent, gloomy teenager who is known on the Internet as "The God of Conquest" for his legendary skills to "conquer" any girl in Bishōjo games, yet does not like girls in real life, where he is known as the Otamegane (オタメガネ), a derogatory portmanteau of the two words otaku (オタク) and Megane (メガネ, lit.
One day, out of pride, he accidentally accepts what he assumes to be a challenge for a Bishōjo game when in reality he has accepted a contract from a bumbling demoness named Elsie who asks for his help in capturing runaway spirits from Hell who are hiding in the hearts of girls.
Together with his intelligence and knowledge of the dating sim genre and Elsie's magical powers, Keima is about to embark on his greatest challenge.
The opening theme is titled "A Whole New World God Only Knows" and is performed by Elisa and LIA under the name "Oratorio The World God Only Knows" and the ending theme song is "Ai no Yokan" (アイノヨカン, lit.
"Premonition Of Love") performed by "The Groove Party God Only Knows" which this time is composed of the second season's voice actresses, Itō, Saori Hayami, Ami Koshimizu, Kana Asumi and Aki Toyosaki.