Hatlo, a sports cartoonist, created the panel to fill space on the comics page of the San Francisco Call-Bulletin.

An occasional feature of They'll Do It Every Time was "Hatlo's History" which enabled the cartoonist to satirize memorable moments from earlier centuries.

In its early decades, a timid man named Henry Tremblechin was a recurring victim of the strip's observations.

Ideas and gags usually came from suggestions by readers, who were credited with a small acknowledgment box with a tiny drawing of Hatlo tipping his hat.

Hatlo continued working on They'll Do It Every Time until his death in 1963 when the team of Al Scaduto and Bob Dunn took over the strip.