Lupton was the youngest of the engravers employed by J. M. W. Turner upon the "Liber Studiorum" ("Book of Studies"), and he executed four of the best of the published and several of the unpublished plates.

His most notable single plates included The Infant Samuel, after Reynolds; Belshazzar's Feast, after John Martin; Wellington surveying the Field of Waterloo, after Benjamin Haydon; The Eddystons Lighthouse and Fishing at Margate, after Turner; some portraits of theatrical groups after Clint, and portraits after Sir Thomas Lawrence, Henry Perronet Briggs, Thomas Phillips, John Watson Gordon, and others.

[1] Lupton also started engraving, a large plate from Turners Calais Pier under the artist's direction, but due to the frequent alterations made by the painter it was never completed.

[1] Between 1868 and 1864, he re-engraved fifteen of the Liber Studiorum subjects for a series intended to be issued in parts, but the project failed and the plates remained unpublished.

His youngest son, Nevil Oliver Lupton, born in 1828, won the "Turner" gold medal of the Royal Academy at the first competition in 1867, and was a frequent exhibitor of landscapes until 1877.