The Saints are currently transitional members of the NCAA's Division II as they move most varsity sports from the Mid-South Conference of the National Association of Intercollegiate Athletics to the NCAA Great Midwest Athletic Conference (G-MAC).

The university will compete in the Great Midwest and be eligible for conference championships and tournaments beginning in the 2023–24 academic year, and, following the mandatory transition period, TMU teams will be eligible for NCAA Championships during the 2025-26 year.

Some sports not sponsored by the G-MAC have separate affiliations; notably, the men's volleyball team competes as a de facto Division I member due to the NCAA sponsoring a single national championship for Divisions I and II.

Thomas More announced its transition to NCAA Division II athletics in July 2022.

Thomas More announced a major comprehensive fundraising campaign in Fall 2021 in support of a five-year strategic plan that includes enhanced athletic facilities for many of the Saints 29 sports teams.