[1] The building is located in the town of Fira, directly above the cliffs which dominate western Santorini.

In the mid-17th century, two modest cave churches were built into the then-solid cliff face.

These churches were eventually destroyed as the cliff receded (due to the ongoing expansion of Fira) and an infirmary was built.

This building was eventually occupied by Jesuits, who lived on the site until the land was given to the Diocese of Santorini.

The current church was built in 1757, and then refurbished and expanded multiple times over the centuries.