Thutmose (Ancient Egyptian: ḏḥwti-msi(.w))[1] was the eldest son of Pharaoh Amenhotep III and Queen Tiye, who lived during the Eighteenth Dynasty of Egypt.

Although he was heir to the throne of his father Amenhotep III, his early death led to the reign of Akhenaten, his younger brother—as the successor to the Egyptian throne—and the intrigues of the century leading up to Ramesses II, the start and ultimately the failure of Atenism, the Amarna letters, and the changing roles of the kingdom's powers.

[3] The miller statuette is inscribed on three sides with this text: Prince Thutmose is best remembered for the limestone sarcophagus of his cat, Ta-miu (she-cat), now in the Cairo Museum.

'[2] Thutmose is also attested by a total of seven pairs of calcite and pottery vases in the Louvre in Paris.

[2] Prince Thutmose disappears from the public records and appears to have died some time during the third decade of Amenhotep III's kingship, fairly late.