[1][2][3] Implementation of TRMS builds on the ability of mass spectrometers to process ions within sub-second duty cycles.
As a concept in analytical chemistry, TRMS encompasses instrumental developments (e.g. interfaces, ion sources, mass analyzers), methodological developments, and applications.
An early application of TRMS was in the observation of flash photolysis process.
[5] TRMS currently finds applications in the monitoring of organic reactions,[6] formation of reactive intermediates,[7] enzyme-catalyzed reactions,[8] convection,[9] protein folding,[10] extraction,[11] and other chemical and physical processes.
TRMS is typically implemented to monitor processes that occur on second to millisecond time scale.