It runs between the Vaupés and the state of Amazonas, in the border region between Colombia and Brazil.

The Tiquié flows into São Gabriel da Cachoeira, forming Lake Mucum in the Vaupés with a surface area of 35 square kilometers.

The highest point nearby reaches 114 m (374 ft) and 1.2 km (0.75 mi) southwest of the Tiquié River.

The vegetation typical of the flooded lands known as igapó abounds, especially dynamic in the lower course.

[1] The Tiquié basin is inhabited by the indigenous peoples Macuna, Tuyuca, Tukano, Bará, Desano, Hudpa and Yuhupdeh.