The town is bordered on the north La Heredad Ranch ranching The Homestead, south to the Tajo de Tequixquiac, east village Hueypoxtla and west by the town of Santiago Tequixquiac.

[3] In Tlapanaloya cross a river Salado de Hueypoxtla, the water most important by irrigation; over hills there are many arroyos and jagueyes.

Tetlapanaloyan was an eleven places of Hueypoxtla province that made a tax payment for the Aztec empire.

[4] This site was an Aztec altepetl (village) inhabited by otomi and nahua people.

In 1542, Tlapanaloya was given in encomienda to Spanish Juan Díaz de Lo Real, he built haciendas over Indian's agricultural lands and pay taxes to Hueypoxtla for Mexico City bishop.