Prince Sanetsune Tokudaiji GCVO (徳大寺 実則, 10 January 1840 – 4 June 1919) was a Japanese statesman and Lord Keeper of the Privy Seal of Japan during the Meiji era.

Tokudaiji Sanetsune was born to a branch of the Fujiwara court nobility in Kyoto.

His father was Tokudaiji Kin'ito, and his brother was Saionji Kinmochi, later Prime Minister of Japan.

Joining the sonnō jōi ("Revere the Emperor, Expel the Barbarian") faction in Court against westernization and the Tokugawa shogunate, he was forced to flee Kyoto during the coup d'état by the moderate samurai of the Aizu and Satsuma domains on 18 August 1863.

In 1891 he became Lord Keeper of the Privy Seal of Japan a post he held until Emperor Meiji's death.