In a dystopian Japan, a mad scientist known as "Key Man" (Itsuji Itao) creates a virus that mutates humans into monstrous creatures called "Engineers" that sprout bizarre biomechanical weapons from injuries.

He massacres the main precinct, causing the Tokyo Police Commissioner (Shun Sugata) to order a city-wide crackdown on Engineers — indiscriminately executing anyone suspected of being one.

Akino's father was a police sniper forced to resign after a failed operation resulted in him sustaining a severe leg injury.

Determined to avenge his father's death, Akino injected himself with the DNA of several infamous criminals, turning himself into the Key Man.

When her friend, a local bar owner (Ikuko Sawada), is drawn and quartered, Ruka's left arm mutates into an alien-like head with razor-sharp claws before she beheads the officers behind the execution.

Following a grueling sword fight, Ruka dismembers and eventually decapitates the commissioner — effectively bringing down his reign on the police force.

While working on special effects for Noboru Iguchi's The Machine Girl, Yoshihiro Nishimura was asked by Media Blasters if he wanted to do another film.

"[13] Russel Edwards of Variety claimed, "Like Tokyo Shock's recent "Machine Girl," for which helmer provided gore effects, [the] pic[ture] will fleetingly exist in midnight sidebars at fests and much longer on fanboy ancillary."

Edwards also said that Tokyo Gore Police had "occasionally witty moments, but the relentless catalog of mutilations lacks the emotional power of similar fare in pics by, say, fellow Japanese gorehound Shinya Tsukomoto [sic].